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NICE NG209 — Tobacco: preventing uptake, promoting quitting and treating dependence

Field Value
Issuing body National Institute for Health and Care Excellence (UK)
Year 2021; last reviewed 4 February 2025
Scope Support to stop smoking for everyone aged 12 and over; harm reduction; prevention of uptake in children, young people and young adults (up to 24)
Source nice.org.uk/guidance/ng209

Key positions

  • Behavioural support: individual or group behavioural support should be offered to everyone who wants to quit; it should not be rationed by "readiness to quit".
  • Medications: varenicline and NRT (alone or combined) are the principal options; bupropion and cytisine are also covered — the 2025 review added new recommendations on cytisinicline (cytisine).
  • E-cigarettes: clinicians can offer nicotine-containing e-cigarettes as an aid for people interested in using them to quit smoking; users should be advised to stop smoking completely.
  • Harm reduction: for people not ready to stop in one go, supports staged reduction, including temporary use of licensed nicotine products.

Notable differences

NG209 is the most e-cigarette-accommodating of the major guidelines: it treats nicotine-containing e-cigarettes as a legitimate offer, in contrast to WHO (insufficient evidence) and USPSTF (I statement). NG209 also explicitly addresses harm reduction and gradual approaches, and extends to people aged 12 and over.