R-005: A randomized trial of e-cigarettes versus nicotine-replacement therapy
| Field | Value |
|---|---|
| Research ID | R-005 |
| Authors | Hajek P, Phillips-Waller A, Przulj D, et al. |
| Year | 2019 |
| Journal / publisher | New England Journal of Medicine |
| DOI | 10.1056/NEJMoa1808779 |
| PMID | Not reported |
| ISBN | Not reported |
| Research type | RCT |
| Evidence strength | Moderate |
| Population | 886 UK adults attending stop-smoking services |
| Intervention | Not reported |
| Comparator | Not reported |
| Last verified | 2026-10-04 |
Main question
Are nicotine e-cigarettes more effective than conventional NRT for quitting smoking?
Main findings
One-year abstinence was 18.0% in the e-cigarette group versus 9.9% in the NRT group. E-cigarette users reported less severe urges and more throat/mouth irritation.
Limitations
Products and setting (UK stop-smoking service with behavioral support) may limit generalizability; long-term safety remains open.
Why this record matters
Not reported
Related topics
Quit Methods; E-cigarettes; Nicotine Replacement Therapy