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R-007: Effects of abstinence from tobacco: valid symptoms and time course

Field Value
Research ID R-007
Authors Hughes JR
Year 2007
Journal / publisher Nicotine & Tobacco Research
DOI 10.1080/14622200701188919
PMID Not reported
ISBN Not reported
Research type Review
Evidence strength Strong
Population Not reported
Intervention Not reported
Comparator Not reported
Last verified 2026-10-04

Main question

Which withdrawal symptoms are valid and how long do they last?

Main findings

Valid withdrawal symptoms include craving, irritability, restlessness, difficulty concentrating, depressed mood, insomnia, and increased appetite. Most symptoms peak in the first week and resolve within 2–4 weeks; craving and increased appetite can persist longer.

Limitations

Derived largely from clinical trial data; individual variation is substantial.

Why this record matters

Not reported

Nicotine Withdrawal; Quit Timeline; Cravings

Source

https://academic.oup.com/ntr/article/9/3/315/1071235