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USPSTF 2021 — Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons

Field Value
Issuing body U.S. Preventive Services Task Force
Year 2021
Publication JAMA 2021;325(3):265-279
DOI 10.1001/jama.2020.25019
PMID 33464343

Recommendations

  • Nonpregnant adults (A recommendation): clinicians should ask all adults about tobacco use, advise stopping, and provide behavioural interventions and FDA-approved pharmacotherapy.
  • Pregnant persons (A recommendation): clinicians should ask about tobacco use, advise stopping, and provide behavioural interventions.
  • Pharmacotherapy in pregnancy (I statement): evidence insufficient to assess balance of benefits and harms.
  • E-cigarettes (I statement): evidence insufficient to assess benefits and harms for cessation in adults; clinicians should direct patients to interventions with proven effectiveness.

Interpretation

The USPSTF position is the reference US preventive-care statement. Its A-grade recommendations mean high certainty of substantial net benefit. The two I statements mark genuine evidence gaps — not "no benefit", but "not yet proven" — which is why this site keeps e-cigarettes in the Controversies section rather than in Methods.